From there, Alexander the Great's fleet for Asia began. With the fall of the Macedonian Kingdom from the Romans, Amphipolis became part of the Roman Empire. The famous Egnatia Road passed through the city. Many tombstones, votive reliefs and statues, as well as gold jewelry have been found in the area. Many vessels were also found that testify to intense commercial movement. Apart from the ancient finds, parts of the ancient walls and the sanctuary of the muse Klios, parts of houses of the Hellenistic and Roman eras are also preserved. Many finds are on display at the Archaeological Museum of Amphipolis.
Amphipolis was an ancient city built in eastern Macedonia, on the banks of the river Strymon, in the place of a city that was formerly called "Nine Roads" or very close to it. Amphipolis was founded by Athenians in 437 BC. with the aim of controlling the area rich in raw materials and was permanently abandoned in the 8th century AD. Today in the area is built the homonymous modern settlement, located about 60 km southeast of Serres. During the reign of Alexander the Great, Amphipolis and its port in the Aegean had developed into a very important naval base for the Macedonians, and the birthplace of three important admirals, Nearchus, Androsthenes and Laomedon.