Pella was founded in 399 BC by King Archelaus as the capital of his kingdom, replacing the older palace-city of Aigai. After this, it was the seat of the king Philip II and of Alexander, his son. In 168 BC, it was sacked by the Romans, and its treasury transported to Rome. Later, the city was destroyed by an earthquake and eventually was rebuilt over its ruins.
Pella is in the beginning of the 4th century BC the largest Macedonian city. It attracted Greek artists. In antiquity, Pella was a port connected to the Thermaic Gulf by a navigable inlet, but the harbor has silted, leaving the site landlocked. The reign of Antigonus likely represented the height of the city, as this is the period which has left us the most archaeological remains. The city went into decline for reasons unknown (possibly an earthquake) by the end of the 1st century BC.